Eddie Irizarry, a NASA solar system ambassador, said binoculars in ideal conditions with little light pollution may also be able to spot the space rock, which is 2.7 miles in size.
The asteroid was discovered in March 1981, and is classified as "potentially hazardous" by the Minor Planet Center.
While the closest approach will be Sept. 1, you can start looking for the asteroid a few nights before. On Aug. 27, 3122 Florence will be in the constellation Piscis Austrinus reaching about 19 degrees above the southern horizon, according to Irizarry.
“Although asteroid Florence is traveling at 30,266 miles per hour (48,708 km/h), the distance will make it appear so slow that observers should keep watching the fairly bright asteroid for about 5 to 10 minutes to detect its movement across the stars,” he said.
Asteroid Florence is named after Florence Nightingale, the founder of modern nursing.