Variety reported that the opening of the film marks the second year in a row that the festival will open with a thriller. Last year, John Krasinski's "A Quiet Place" marked the start of the festivities.
The Wrap reported that SXSW will release its full list of films Jan. 16 and the festival will be held March 8-17.
"Us" will be in theaters March 15. The movie trailer can be watched below.