Mrs. Spencer was 99 at the time of her death on July 9.
Her legacy includes her being the first female president of the Cincinnati Banch NAACP, the first African-American woman on city council as well as the first female vice mayor.
Her work also was essential in the fight for equality at UC, where she and other black people were not allowed to live in the dormitories when she was a student there in the late 1930s and early 1940s.
In 2018, UC's Marian Spencer Hall was dedicated to pay homage to her work.
The celebration at the arena will feature singing, guest speakers, authors, the Cincinnati Symphony Orchestra, the Spencer family and a reception following the free event that begins Saturday at 3 p.m. Arena doors open at 1 p.m.