By 1955, the company sold a million Beetles, The Associated Press reported.
It didn't take center stage in pop culture until the Disney film "The Love Bug" hit theaters in 1968 and starred Herbie, the anthropomorphic race car.
It then became popular during the late '60s and '70s. It ended production in Mexico in 2003. More than 21 million cars were made before the line was retired.
Eventually, the biggest foreign market for the car was the United States, which drove 40% of the vehicle's production run in 1968, the AP reported.
Production of the Beetle ended in Germany in 1978, but the plant in Mexico, which started producing the cars in 1967, continued building them until 2003, the AP reported.
There were two redesigns, one in 1998 and another in 2012.
The final Beetle, which will be honored in a ceremony Wednesday, will go directly from the assembly line to a Volkswagen museum, CNN reported.
The factory that produced the Beetle will be used to make a compact SUV for the North American market.