The billboard is directly above the Silver Moon II restaurant, PETA said in its release.
"Whatever they say, 'Go vegan,' whatever, nothing is going to work," Nick Lentis, owner of Silver Moon II, told WBAL."Vegan is for vegan. Do what you have to do. Eat what you have to eat. Don't press the people to go do that, so leave the people alone."
Lentis said that since the image of the billboard has gone viral, it has affected his business.
"I don't have nothing to do with this. I sell crab meat," Lentis told WJZ. "I think they have to remove it."
PETA has erected similar billboards in other cities. There is a lobster-themed pro-vegan advertisement at the Maine International Jetport, The Sun of Baltimore reported.
PETA officials said they plan to keep the billboard up through the
Baltimore Seafood Festival on Sept. 15.
The reaction of some Baltimore residents has been, well, crabby.
"Um. You are a crustacean that has been around for millions of years and is part of a food chain that feeds animals and humans. Try again," one person tweeted.