Survivors include Witherspoon's wife, Angela, and sons Alexander and J.D., his family told Deadline. The latter took to Twitter to share several throwback photos of him and his father.
"So ... my Dad died today & honestly I'm not sure how to feel," J.D. Witherspoon tweeted. "I'm sad, but I'm also happy 4 all the great times we had together. We'd roast each other like homies more than Father & Son, and I really liked that. He was my best friend & my idol. Love U Dad...I'll miss u."
Fellow celebrities and friends paid tribute to Witherspoon on social media, as well.
"I'm devastated over the passing of John Witherspoon," Ice Cube wrote in a tweet. "Life won't be as funny without him."
"You were my TV dad and my mentor and my friend," actor and comedian Marlon Wayans added in an Instagram post. "I miss you already."
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– The Associated Press contributed to this report.